Description

S-Methyl-L-Thiocitrulline, Hydrochloride is a high-purity, chemically modified derivative of the amino acid L-citrulline, specifically designed for advanced biochemical and pharmaceutical research. This compound serves as a critical tool molecule for investigating nitric oxide synthase (NOS) activity and related cellular signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in metabolic studies, enzyme inhibition assays, and the development of novel therapeutic agents.

Application

• Biochemical Research: As a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) for studying the role of nitric oxide in inflammation and immune response.
• Pharmaceutical Development: A key intermediate or reference standard in the discovery and development of new drugs targeting cardiovascular diseases, neurodegenerative disorders, and inflammatory conditions.
• Enzyme Kinetics Studies: Used to characterize the binding affinity and inhibition mechanisms of nitric oxide synthase isoforms in vitro.
• Cell Signaling Pathway Analysis: Employed in cell-based assays to elucidate the downstream effects of NOS inhibition on gene expression and cellular function.
• Academic Research: A valuable reagent for university laboratories focusing on biochemistry, molecular biology, and medicinal chemistry projects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	S-Methyl-L-Thiocitrulline, Hydrochloride
CAS No.	156719-39-0
Molecular Formula	C7H15N3O2S • HCl
Molecular Weight	241.73 g/mol (free base: 205.28 g/mol)
Synonyms	S-Methyl-L-thiocitrulline HCl; S-Methyl-L-thiocitrulline hydrochloride; (2S)-2-Amino-5-[(carbamimidoyl)methylsulfanyl]pentanoic acid hydrochloride; L-Thiocitrulline, S-methyl-, hydrochloride; NOS Inhibitor; iNOS Inhibitor; S-Methylthiocitrulline HCl
EINECS	Contact for details

Quality Control

Our S-Methyl-L-Thiocitrulline, Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.