Description

L-Thiocitrulline is a sulfur-containing analog of the amino acid L-citrulline, characterized by the replacement of an oxygen atom with a sulfur atom in the ureido group. This structural modification makes it a valuable biochemical tool and a key intermediate in the research and development of nitric oxide synthase (NOS) inhibitors and other bioactive compounds. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in metabolic pathway studies, enzyme mechanism investigations, and novel drug discovery. The compound's unique properties offer significant potential for advancing scientific understanding in cardiovascular and neurological research areas.

Application

• Biochemical Research: Used as a critical substrate or inhibitor in enzymatic studies, particularly for investigating nitric oxide synthase (NOS) isoforms and related arginine metabolism pathways.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of potential therapeutic agents targeting conditions related to nitric oxide dysregulation.
• Proteomics & Metabolomics: Employed as a standard or reagent in mass spectrometry and analytical methods for studying post-translational modifications and sulfur-containing metabolites.
• Academic Research: Utilized in university and institutional labs for fundamental studies in biochemistry, cell signaling, and molecular biology.
• Diagnostic Development: Acts as a component in developing assay kits and diagnostic tools for measuring enzyme activity or metabolic markers.
• Fine Chemical Synthesis: Incorporated into multi-step synthetic routes for creating specialized, high-value chiral compounds and analogs.

Basic Information

Product Name	L-Thiocitrulline
CAS No.	156719-37-8
Molecular Formula	C₆H₁₃N₃O₂S
Molecular Weight	191.25 g/mol
Synonyms	(S)-2-Amino-5-(carbamimidamido)pentanoic acid; (S)-2-Amino-5-(carbamimidoylcarbamothioylamino)pentanoic acid; L-2-Amino-5-ureidopentanoic acid thioamide; Thiocitrulline; S-Amino-5-ureidovaleric acid thioamide; NSC 339313
EINECS	Contact for details

Quality Control

Our L-Thiocitrulline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, ensuring compliance with research-grade specifications. Our commitment to quality assurance guarantees material integrity and reliable performance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.