Description

Cyclo(Ala-Phe-Trp-Lys-Val-Phe) is a synthetic cyclic hexapeptide composed of the amino acids Alanine, Phenylalanine, Tryptophan, Lysine, and Valine. This structurally constrained peptide is of significant interest in pharmaceutical research and development due to its potential for enhanced metabolic stability and receptor selectivity compared to linear analogs. It serves as a critical intermediate and research tool for scientists in medicinal chemistry, peptide therapeutics, and biochemical screening. The compound, identified by CAS No. 156586-93-5, is utilized in the development of novel bioactive compounds targeting various disease pathways.

Application

• Pharmaceutical Research & Development: As a key scaffold or intermediate in the discovery and optimization of novel peptide-based therapeutics.
• Medicinal Chemistry: For structure-activity relationship (SAR) studies to understand the impact of cyclization on bioactivity and pharmacokinetic properties.
• Biochemical Reagent: Used in enzymatic assays, receptor binding studies, and as a standard in analytical method development for peptide analysis.
• Academic Research: Investigation of peptide conformation, stability, and interactions in biochemical and biophysical studies.
• Preclinical Studies: Evaluation of efficacy, toxicity, and metabolic profiles in early-stage drug development programs.

Basic Information

Product Name	Cyclo(Ala-Phe-Trp-Lys-Val-Phe)
CAS No.	156586-93-5
Molecular Formula	C44H54N10O6
Molecular Weight	818.98 g/mol
Synonyms	Cyclo(Alanine-Phenylalanine-Tryptophan-Lysine-Valine-Phenylalanine); Cyclo(AFWKVF); c(AFWKVF); Cyclic Hexapeptide AFWKVF; 156586-93-5; Cyclo(L-alanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-valyl-L-phenylalanine); L-Alanine, L-phenylalanyl-L-tryptophyl-L-lysyl-L-valyl-L-phenylalanine, cyclic (1→6)-peptide
EINECS	Contact for details

Quality Control

Our Cyclo(Ala-Phe-Trp-Lys-Val-Phe) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, residual solvents, and other critical parameters to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.