Description

α-Methylhomocysteine Thiolactone is a specialized heterocyclic organosulfur compound featuring a thiolactone ring. This high-purity building block is critical for advanced organic synthesis and biochemical research, enabling the controlled introduction of a modified homocysteine moiety. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel cysteine protease inhibitors and other bioactive molecules targeting metabolic pathways.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to homocysteine metabolism and transsulfuration pathways.
• Peptide Chemistry: Serves as a protected or modified amino acid derivative for the synthesis of complex peptides and peptidomimetics.
• Reference Standard: Employed as an analytical standard in method development and quality control for related pharmaceutical compounds.
• Chemical Biology Probes: Useful for creating activity-based probes to study enzyme function and mechanism in biological systems.

Basic Information

Item	Details
Product Name	α-Methylhomocysteine Thiolactone
CAS No.	156574-58-2
Molecular Formula	C6H9NOS
Molecular Weight	143.21 g/mol
Synonyms	2-Amino-4-(methylthio)butyric acid thiolactone; L-α-Methylhomocysteine thiolactone; (S)-2-Amino-4-(methylmercapto)butyric acid thiolactone; 2-Amino-4-(methylsulfanyl)butanoic acid thiolactone; Homocysteine thiolactone, α-methyl-; 3,4-Dihydro-2H,5H-2-methylthiophene-5-one; 5-Methyldihydro-2H-thiophen-5-one; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our α-Methylhomocysteine Thiolactone is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.