Description

Rapacuronium CAS NO 156137-99-4 is a non-depolarizing neuromuscular blocking agent belonging to the aminosteroid class. It is a critical pharmaceutical intermediate and active ingredient used in the development and manufacturing of anesthetic formulations. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on developing and producing short-acting muscle relaxants for surgical and intensive care applications.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in injectable neuromuscular blocking agents.
• Anesthesia Adjunct: Used in surgical procedures to induce muscle relaxation, facilitating endotracheal intubation and improving surgical conditions.
• Research & Development: A key reference standard and intermediate in pharmacological research for studying neuromuscular transmission and developing new anesthetic agents.
• Generic Drug Manufacturing: Serves as the core component for the production of generic rapacuronium bromide formulations.
• Clinical Trial Material: Supplied as a high-purity compound for use in clinical studies and bioequivalence testing.
• Veterinary Medicine: Potential application in veterinary anesthesia for large animals during surgical procedures.

Basic Information

Product Name	Rapacuronium
CAS No.	156137-99-4
Molecular Formula	C32H53N2O4+
Molecular Weight	529.78 g/mol
Synonyms	Rapacuronium Bromide; Org 9487; (3α,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl 1-(2-propenyl)pyrrolidinium Bromide; 16-N-Allyl-17-acetyl-3-acetoxy-2β-piperidino-5α-androstane Methobromide; 2β,16β-Bis-[1-(allyl)pyrrolidinio]-3α,17β-diacetoxy-5α-androstane Dibromide; 2β,16β-Dipiperidino-3α,17β-diacetoxy-5α-androstane Dimethobromide; BW A938U; ZEMURON (as the bromide salt)
EINECS	Contact for details

Quality Control

Our Rapacuronium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) that comply with cGMP guidelines, ensuring the material meets the high standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.