Description

n-Fmoc-3-Iodo-L-Alanine Methyl Ester is a high-purity, protected amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for the controlled introduction of iodinated alanine residues, enabling the creation of structurally complex and biologically active peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel peptide-based therapeutics and diagnostic probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the Fmoc-strategy synthesis of peptides containing 3-iodoalanine, a valuable non-natural amino acid for structure-activity relationship (SAR) studies.
• Medicinal Chemistry & Drug Discovery: Used to incorporate iodine atoms into peptide backbones for radioiodination, bioconjugation, or as a heavy atom for X-ray crystallography studies of protein-ligand interactions.
• Chemical Biology Probes: Serves as a precursor for synthesizing activity-based probes or affinity tags to study enzyme function and protein-protein interactions.
• Pharmaceutical Intermediate: An essential raw material in the research and development pipeline for novel peptide drugs targeting various diseases.
• Academic Research: Employed in university and institutional labs for investigating peptide structure, function, and developing new synthetic methodologies.

Basic Information

Product Name	n-Fmoc-3-Iodo-L-Alanine Methyl Ester
CAS No.	156017-42-4
Molecular Formula	C19H18INO4
Molecular Weight	451.16 g/mol
Synonyms	(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropanoic acid methyl ester; Fmoc-3-Iodo-L-Ala-OMe; Fmoc-3-Iodo-L-alanine methyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-iodo-L-alanine methyl ester; Methyl (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-iodopropanoate; (S)-Methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-iodopropanoate
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-Iodo-L-Alanine Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Heavy Metals	<10 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.