Description

4-Chloro-6-(2,2,2-trifluoroethoxy)pyrimidine is a high-value fluorinated pyrimidine building block, essential for advanced organic synthesis. Its core value lies in the strategic combination of a reactive chlorine atom and a trifluoroethoxy group, enabling precise molecular modifications. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing novel active ingredients, such as kinase inhibitors and herbicides.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for targeted cancer therapies and kinase inhibitors.
• Agrochemical Research: Serves as a crucial building block for developing new-generation herbicides and fungicides with enhanced efficacy and environmental profiles.
• Material Science: Used in the research and development of advanced materials, including liquid crystals and organic semiconductors, where fluorine substitution is critical.
• Chemical Synthesis: Acts as a versatile precursor for further functionalization via nucleophilic aromatic substitution (SNAr) reactions at the chloro position.
• Life Science Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.

Basic Information

Product Name	4-Chloro-6-(2,2,2-trifluoroethoxy)pyrimidine
CAS No.	155957-47-4
Molecular Formula	C6H4ClF3N2O
Molecular Weight	212.56 g/mol
Synonyms	4-Chloro-6-(2,2,2-trifluoroethoxy)pyrimidine; 6-(2,2,2-Trifluoroethoxy)-4-chloropyrimidine; 4-Chloro-6-(trifluoroethoxy)pyrimidine; Pyrimidine, 4-chloro-6-(2,2,2-trifluoroethoxy)-; 155957-47-4; 4-Chloro-6-(2,2,2-trifluoroethoxy)pyrimidine (CAS 155957-47-4); 4-Chloro-6-(trifluoroethoxyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(2,2,2-trifluoroethoxy)pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.