Description

Agitoxin-3 CAS NO 155646-23-4 is a highly selective and potent peptide neurotoxin that specifically blocks certain voltage-gated potassium channels (Kv1.x family). This compound is a critical research tool for neuroscientists and pharmacologists studying ion channel function, structure, and their role in various physiological and pathological processes. It is essential for academic research, pharmaceutical discovery, and biotechnology applications focused on neurological targets.

Application

• Neuroscience Research: A fundamental tool for studying the biophysics, pharmacology, and molecular biology of potassium channels (Kv1.1, Kv1.3, Kv1.6) in neuronal signaling.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and characterize novel modulators of potassium channels for potential therapeutic applications.
• Biochemical & Structural Studies: Employed in binding studies, channel purification, and as a molecular probe to elucidate channel architecture and gating mechanisms.
• Toxicology & Venom Research: Serves as a reference standard for the study of scorpion venom peptides and their mode of action.
• Academic & Institutional Laboratories: Used in university and government research labs for fundamental biological research and teaching advanced concepts in neuropharmacology.

Basic Information

Product Name	Agitoxin-3
CAS No.	155646-23-4
Molecular Formula	C185H274N52O53S7
Molecular Weight	~4210.9 g/mol
Synonyms	AgTx3; Agitoxin 3; Leiurotoxin I; Iberiotoxin; Kaliotoxin; KTX; Neurotoxin BmKTX; Potassium channel toxin α-KTx 3.6; ShK toxin analogue
EINECS	Contact for details

Quality Control

Our Agitoxin-3 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC for purity and mass spectrometry for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Potency (Bioassay)	≥ 98%
Water Content (KF)	≤ 5.0%
Endotoxin Level (LAL)	< 1.0 EU/µg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.