Description

Agitoxin 2 CAS NO 155646-22-3 is a highly selective and potent peptide toxin that specifically blocks certain voltage-gated potassium channels (Kv1.x family). This compound is a critical research tool in neuroscience and electrophysiology for studying ion channel function, neuronal excitability, and related disease mechanisms. It is essential for pharmaceutical R&D, academic research, and diagnostic applications focused on neurological disorders and cardiac electrophysiology.

Application

• Neuroscience Research: A key pharmacological tool for studying the structure, function, and modulation of voltage-gated potassium (Kv) channels, particularly Kv1.1, Kv1.2, and Kv1.3 subtypes.
• Electrophysiology Studies: Used in patch-clamp and other electrophysiological assays to selectively inhibit specific potassium currents, enabling the isolation and characterization of channel subtypes in cells and tissues.
• Drug Discovery & Development: Serves as a reference standard and screening tool in the development of novel therapeutics targeting potassium channels for conditions like autoimmune diseases, neurological disorders, and cardiac arrhythmias.
• Biochemical Assays: Employed in binding studies, receptor autoradiography, and the development of diagnostic assays to quantify channel expression or screen for channel modulators.
• Toxicology & Venom Research: Studied as a component of scorpion venom for understanding toxin-channel interactions and the mechanisms of animal envenomation.

Basic Information

Product Name	Agitoxin 2
CAS No.	155646-22-3
Molecular Formula	C185H274N52O53S7
Molecular Weight	4213.0 g/mol (approximately)
Synonyms	AgTx2; Agitoxin-2; Leiurotoxin II; Iberiotoxin homolog; Potassium channel toxin α-KTx 3.6; α-KTx3.6; Leiurus quinquestriatus hebraeus toxin 2
EINECS	Contact for details

Quality Control

Our Agitoxin 2 is produced and tested under stringent quality protocols to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and biological potency. We adhere to relevant standards for research-grade biochemicals to support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (typically nM range for Kv1.3)
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.