Description

Agitoxin 1 CAS NO 155646-21-2 is a highly specific and potent peptide toxin that selectively inhibits certain voltage-gated potassium channels. This compound is a critical research tool for neuroscientists and pharmacologists studying ion channel function, neuronal excitability, and related disease mechanisms. It is primarily utilized in academic, pharmaceutical, and biotechnology research settings for electrophysiology studies, assay development, and the investigation of neurological disorders.

Application

• Neuroscience Research: A key pharmacological tool for blocking specific Kv1.x potassium channel subtypes in electrophysiological experiments to study neuronal signaling and action potential generation.
• Ion Channel Pharmacology: Used in high-throughput screening (HTS) assays and target validation studies to discover and characterize novel modulators of potassium channels.
• Drug Discovery & Development: Serves as a reference standard and positive control in the development of therapeutics targeting potassium channel dysfunction in conditions like epilepsy, ataxia, and autoimmune disorders.
• Toxicology & Venom Studies: Employed in comparative studies of animal venoms and the structure-activity relationships (SAR) of peptide toxins.
• Biochemical Assays: Used in binding studies (e.g., radioligand or fluorescence-based displacement assays) to determine receptor affinity and kinetics.
• Academic & Educational Use: An essential reagent for university laboratories and courses focused on cellular physiology, neurobiology, and molecular pharmacology.

Basic Information

Product Name	Agitoxin 1
CAS No.	155646-21-2
Molecular Formula	C185H274N52O55S7
Molecular Weight	4214.9 g/mol
Synonyms	Agitoxin-1; AgTX1; Leiurus quinquestriatus hebraeus toxin 1; Potassium channel toxin α-KTx 3.6; Charybdotoxin-2; Lqhag1; ShK-like peptide toxin; Voltage-gated potassium channel blocker agitoxin-1
EINECS	Contact for details

Quality Control

Our Agitoxin 1 is produced and purified under stringent conditions to ensure the highest standards of biological activity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques, including reversed-phase HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Each batch is supplied with a detailed Certificate of Analysis (COA) documenting purity, peptide content, and biological activity data where applicable, supporting research reproducibility and compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored at -80°C. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Solubility	Soluble in water or aqueous buffers
Biological Activity (IC50)	Specified per batch (nM range, Kv1.3/Kv1.1)
Endotoxin Level	< 1.0 EU/μg (where specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.