Description

3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, multifunctional heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of novel, potent antibacterial agents, specifically fluoroquinolone antibiotics. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced fluoroquinolone antibiotic candidates.
• Antibacterial Drug Discovery: Serves as a core scaffold for medicinal chemistry programs targeting DNA gyrase and topoisomerase IV inhibition.
• API Manufacturing: Used in the scaled-up production of active pharmaceutical ingredients for clinical trials and commercial supply.
• Biochemical Research: Valuable tool compound for studying bacterial resistance mechanisms and structure-activity relationships (SAR).
• Process Chemistry Development: Employed in optimizing synthetic routes for cost-effective and high-yield production of complex drug molecules.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-
CAS No.	155421-11-7
Molecular Formula	C19H18ClF2N3O3
Molecular Weight	409.82 g/mol
Synonyms	7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; (1R,2S)-1-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1,4-dihydro-4-oxo-7-(3-quinolinyl)-3-quinolinecarboxylic acid (related structural name); Advanced Fluoroquinolone Intermediate; Antibacterial Spirocyclic Intermediate; CAS 155421-11-7.
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and residual solvents are provided with every shipment. We support development and commercial projects requiring material that meets ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Single Maximum Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.