Description

5-Amino-2-Iodobenzotrifluoride is a high-value halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique trifluoromethyl and iodo substituents adjacent to an amino group make it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the halogen and amino groups for effective binding to biological targets.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis, including cross-coupling reactions like Suzuki and Buchwald-Hartwig amination.
• Material Science Research: Employed in the creation of organic electronic materials, such as charge-transport layers or fluorinated polymers, due to its electron-withdrawing trifluoromethyl group.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes, where the iodine atom allows for further functionalization via halogen exchange.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated aniline architectures.

Basic Information

Product Name	5-Amino-2-Iodobenzotrifluoride
CAS No.	155403-06-8
Molecular Formula	C7H5F3IN
Molecular Weight	287.02 g/mol
Synonyms	2-Iodo-5-aminobenzotrifluoride; 5-Amino-2-iodo-α,α,α-trifluorotoluene; 2-Iodo-α,α,α-trifluoro-m-toluidine; 3-Amino-6-iodobenzotrifluoride; 2-Iodo-5-(trifluoromethyl)aniline; 5-(Trifluoromethyl)-2-iodoaniline; Benzenamine, 2-iodo-5-(trifluoromethyl)-; 155403-06-8
EINECS	Contact for details

Quality Control

Our 5-Amino-2-Iodobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	72 - 76 °C
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.