Description

L-2-Amino-3-[Thiomethyl-1-(1-Oxyl-2,2,5,5-Tetramethyl-3-Pyrrolin-3-Yl)]Propanoic Acid is a specialized, high-purity amino acid derivative containing a stable nitroxide radical, making it a critical spin label and probe in advanced research. This compound matters for its unique paramagnetic properties, which are essential for techniques like Electron Paramagnetic Resonance (EPR) spectroscopy and site-directed spin labeling (SDSL) to study protein dynamics and structure. It is primarily needed by research institutions, pharmaceutical R&D departments, and advanced material scientists developing next-generation diagnostic tools and studying biomolecular interactions.

Application

• Biophysical Research & EPR Spectroscopy: As a site-specific spin label for probing protein folding, conformational changes, and macromolecular interactions.
• Structural Biology: Used in Site-Directed Spin Labeling (SDSL) to determine distances and dynamics within proteins and nucleic acids.
• Pharmaceutical R&D: Employed in drug discovery to study ligand-receptor binding and membrane protein dynamics.
• Advanced Material Science: As a building block for creating functionalized polymers and surfaces with paramagnetic properties.
• MRI Contrast Agent Development: Serves as a precursor or model compound for designing novel contrast agents.
• Antioxidant Research: Used to study free radical processes and oxidative stress mechanisms in biological systems.

Basic Information

Product Name	L-2-Amino-3-[Thiomethyl-1-(1-Oxyl-2,2,5,5-Tetramethyl-3-Pyrrolin-3-Yl)]Propanoic Acid
CAS No.	155313-72-7
Molecular Formula	C13H23N2O3S
Molecular Weight	287.40 g/mol
Synonyms	MTSSL Amino Acid; (S)-2-Amino-3-((((1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)thio)propanoic acid; 3-Maleimido-PROXYL labeled cysteine analog; 1-Oxyl-2,2,5,5-tetramethyl-δ3-pyrroline-3-methylthio cysteine; S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl-L-cysteine; PROXYL spin-labeled cysteine derivative; Nitroxide-labeled amino acid; EPR spin label amino acid.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with the high-purity standards required for sensitive research applications. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and EPR spectroscopy to confirm identity, purity, and radical integrity. Certificates of Analysis (COA) detailing assay, impurity profile, and specific rotation are available upon request. We adhere to a quality management system suitable for supplying research and development organizations globally.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability, as the compound is easily oxidized and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
EPR Signal	Characteristic triplet spectrum
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.