Description

Amyloid β-Protein (17-42) is a synthetic peptide fragment corresponding to a key region of the amyloid-beta protein, a primary component of amyloid plaques found in the brains of individuals with Alzheimer's disease. This high-purity peptide is critical for advancing research into the molecular mechanisms of protein aggregation, neurotoxicity, and disease pathology. It is an essential biochemical tool for neuroscientists, pharmaceutical researchers, and diagnostic developers working in neurodegenerative disease research, drug discovery, and in vitro assay development.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, structural properties, and toxicity of amyloid-beta peptides.
• Drug Discovery & Screening: Used as a target or substrate in high-throughput screening (HTS) assays to identify potential therapeutic compounds that inhibit aggregation or promote clearance.
• Antibody & Diagnostic Development: Serves as an antigen for the production and characterization of antibodies used in ELISA, Western blot, and immunohistochemistry for Alzheimer's disease research.
• Biophysical Studies: Investigation of peptide-membrane interactions, fibril formation, and structural analysis using techniques like NMR, CD spectroscopy, and electron microscopy.
• Cell Culture & In Vitro Models: Induction of cytotoxic effects in neuronal cell cultures to model disease mechanisms and test neuroprotective agents.
• Reference Standard: Acts as a qualified reference material for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Amyloid β-Protein (17-42)
CAS No.	155178-13-5
Molecular Formula	C130H203N41O43S
Molecular Weight	2990.3 g/mol
Synonyms	Aβ(17-42); Amyloid β-Protein (17-42); β-Amyloid Peptide (17-42); Amyloid Beta (17-42); Aβ17-42; Amyloid-β (17-42); Alzheimer's Disease Amyloid Peptide (17-42); LVFFAEDVGSNKGAIIGLMVGGVVIA
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (17-42) is manufactured under strict conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or dilute acetic acid
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.