Description

Glycoprotein IIb Fragment (300-312) is a synthetic peptide sequence corresponding to a specific region of the platelet integrin glycoprotein IIb/IIIa complex. This compound is of significant value in biochemical and pharmaceutical research for studying platelet aggregation, thrombosis, and related cardiovascular mechanisms. It serves as a critical tool for researchers and developers in the fields of hematology, cardiovascular drug discovery, and diagnostic assay development.

Application

• Biochemical Research: Used as a reference standard or inhibitor in studies of platelet activation and fibrinogen binding mechanisms.
• Drug Discovery: Serves as a key antigen or target peptide in the development of anti-thrombotic and anti-platelet therapeutic agents.
• Immunoassay Development: Employed in the production and calibration of antibodies for diagnostic tests targeting platelet disorders.
• Structure-Activity Relationship (SAR) Studies: Utilized to map critical binding domains and understand the interaction between glycoprotein IIb/IIIa and its ligands.
• Academic & Clinical Research: Applied in laboratory investigations into hemostasis, thrombosis, and cardiovascular diseases.

Basic Information

Product Name	Glycoprotein IIb Fragment (300-312)
CAS No.	155114-45-7
Molecular Formula	C68H108N18O21S
Molecular Weight	1521.8 g/mol
Synonyms	GPIIb Fragment (300-312); Glycoprotein IIb (300-312); Platelet Glycoprotein IIb Peptide (300-312); H-HHTDGYRMDLACTC-OH; Integrin α-IIb Fragment; Fibrinogen Receptor Peptide; Arg-Gly-Asp (RGD) containing peptide analog; Antiplatelet target peptide
EINECS	Contact for details

Quality Control

Our Glycoprotein IIb Fragment (300-312) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 8.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.