Description

3-[[6-Bromo-3-(3-Hydroxy-4-Methoxycarbonyl-Phenyl)-4-Oxo-Quinazolin-2- Yl]Methylsulfanyl]Propanoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex quinazolinone-based molecular structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel drug candidates, especially in oncology and other disease areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel quinazolinone-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Oncology Drug Development: A potential precursor for tyrosine kinase inhibitors and other targeted cancer therapies due to its specific bromo and methoxycarbonyl functional groups.
• Chemical Biology Probes: Employed in the development of chemical probes to study enzyme function and biological pathways.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis and heterocyclic chemistry studies.

Basic Information

Product Name	3-[[6-Bromo-3-(3-Hydroxy-4-Methoxycarbonyl-Phenyl)-4-Oxo-Quinazolin-2- Yl]Methylsulfanyl]Propanoic Acid
CAS No.	155104-14-6
Molecular Formula	C20H15BrN2O5S
Molecular Weight	475.31 g/mol
Synonyms	6-Bromo-3-(3-hydroxy-4-(methoxycarbonyl)phenyl)-2-((3-carboxypropyl)thio)-4(3H)-quinazolinone; Propanoic acid, 3-[[6-bromo-3-[3-hydroxy-4-(methoxycarbonyl)phenyl]-4-oxo-2-quinazolinyl]methylthio]-; 2-[(3-Carboxypropyl)thio]-6-bromo-3-[3-hydroxy-4-(methoxycarbonyl)phenyl]-4(3H)-quinazolinone; 3-({[6-Bromo-3-(3-hydroxy-4-methoxycarbonylphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]methyl}thio)propanoic acid; BRQ Intermediate; Quinazolinone carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 3-[[6-Bromo-3-(3-Hydroxy-4-Methoxycarbonyl-Phenyl)-4-Oxo-Quinazolin-2- Yl]Methylsulfanyl]Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and residual solvent analysis are provided with every shipment. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.