Description

D-Norleucine, 5,5-Difluoro- (9Ci) is a specialized, non-natural amino acid derivative featuring a difluoromethyl group at the 5-position. This compound matters as a high-value building block in medicinal chemistry, where the strategic incorporation of fluorine atoms can dramatically alter a molecule's metabolic stability, lipophilicity, and binding affinity. It is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel bioactive compounds and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in protease inhibitor and peptide mimetic programs.
• Medicinal Chemistry Building Block: Used to introduce the difluoro-norleucine moiety into target molecules to study structure-activity relationships (SAR) and optimize pharmacokinetic properties.
• Agrochemical Research: Serves as a precursor in the synthesis of advanced, fluorinated active ingredients with potential herbicidal or insecticidal activity.
• Biochemical Tool Compound: Employed in biochemical assays and studies to investigate enzyme mechanisms and metabolic pathways involving amino acid analogs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to create fluorinated peptide analogs for biological evaluation.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and pilot-scale production of target molecules in development pipelines.

Basic Information

Product Name	D-Norleucine, 5,5-Difluoro- (9Ci)
CAS No.	154967-78-9
Molecular Formula	C6H11F2NO2
Molecular Weight	167.16 g/mol
Synonyms	D-5,5-Difluoronorleucine; (R)-2-Amino-5,5-difluorohexanoic acid; D-2-Amino-5,5-difluorohexanoic acid; (R)-5,5-Difluoronorleucine; D-5,5-Difluoro-2-aminohexanoic acid; (2R)-2-Amino-5,5-difluorohexanoic acid; 154967-78-9
EINECS	Contact for details

Quality Control

Our D-Norleucine, 5,5-Difluoro- (9Ci) is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, and specifications can be aligned with customer-specific requirements for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.