Description

Ethyl 4-(4-Chlorophenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel pharmacologically active molecules, particularly within the dihydropyrimidinone (DHPM) scaffold family. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for creating new drug candidates and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of dihydropyrimidinone (DHPM) derivatives, which are explored for a wide range of biological activities including antiviral, antibacterial, anti-inflammatory, and calcium channel modulating properties.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its heterocyclic core for potential herbicidal or fungicidal activity.
• Chemical Synthesis Building Block: Employed in multi-step organic synthesis for constructing complex molecular architectures due to its reactive functional groups (ester, thioxo, tetrahydropyrimidine).
• Academic & Institutional R&D: Utilized in universities and research institutes for methodological studies in heterocyclic chemistry and medicinal chemistry programs.
• Material Science Exploration: Investigated as a potential monomer or precursor for specialty polymers and advanced organic materials with specific electronic or structural properties.

Basic Information

Product Name	Ethyl 4-(4-Chlorophenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	154866-92-9
Molecular Formula	C₁₄H₁₅ClN₂O₂S
Molecular Weight	310.80 g/mol
Synonyms	Ethyl 4-(4-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbethoxy-4-(4-chlorophenyl)-6-methyl-3,4-dihydro-2(1H)-pyrimidinethione; 4-(4-Chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; Biginelli Reaction Derivative; DHPM Derivative; 154866-92-9; 4-(p-Chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-(4-Chlorophenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ISO 9001 quality management principles, and specifications can be developed to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.