Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-2-Chloro-4-(Trifluoromethyl)-5-Pyrimidinecarboxamide is a high-value, multi-fluorinated pyrimidine derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring multiple trifluoromethyl groups, imparts significant lipophilicity and metabolic stability, making it a sought-after intermediate for research and development. This compound is primarily utilized by pharmaceutical and agrochemical R&D teams focused on creating novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel small-molecule drugs, particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and coatings with unique fluorinated properties.
• Chemical Biology Probe: Employed in medicinal chemistry to study structure-activity relationships (SAR) and optimize lead compounds.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-2-Chloro-4-(Trifluoromethyl)-5-Pyrimidinecarboxamide
CAS No.	154563-54-9
Molecular Formula	C14H5ClF9N3O
Molecular Weight	437.64 g/mol
Synonyms	2-Chloro-N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoromethyl)pyrimidine-5-carboxamide; 154563-54-9; 2-Chloro-4-(trifluoromethyl)-N-[3,5-bis(trifluoromethyl)phenyl]pyrimidine-5-carboxamide; 5-Pyrimidinecarboxamide, N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-; Pyrimidine-5-carboxamide, 2-chloro-N-[3,5-bis(trifluoromethyl)phenyl]-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of our n-[3,5-Bis(Trifluoromethyl)Phenyl]-2-Chloro-4-(Trifluoromethyl)-5-Pyrimidinecarboxamide is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the exacting standards required for research and process development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.