Description

Uroguanylin (Human) is a 16-amino acid peptide hormone that plays a critical role in regulating intestinal fluid and electrolyte homeostasis. It is a key endogenous ligand for the guanylyl cyclase C (GC-C) receptor, making it a vital compound for physiological research and therapeutic development. This high-purity peptide is essential for researchers and developers in the pharmaceutical and biotechnology sectors focusing on gastrointestinal disorders, cystic fibrosis, and novel drug discovery.

Application

• Biomedical Research: Fundamental studies on intestinal fluid secretion, electrolyte transport, and the guanylin peptide family's physiological functions.
• Drug Discovery & Development: Serving as a reference standard and a lead compound for developing novel therapeutics targeting GC-C receptors for conditions like constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.
• In Vitro & In Vivo Assays: Used in cell-based assays and animal models to study receptor binding, signal transduction pathways, and the efficacy of related drug candidates.
• Diagnostic Tool Development: Potential use in developing assays to measure endogenous uroguanylin levels for research into metabolic and cardiovascular diseases.
• Peptide Chemistry & Synthesis: As a benchmark for synthetic peptide chemistry, purity analysis, and stability studies.

Basic Information

Item	Detail
Product Name	Uroguanylin (Human)
CAS No.	154525-25-4
Molecular Formula	C78H122N24O25S4
Molecular Weight	1884.2 g/mol
Synonyms	Human Uroguanylin; Uroguanylin-18; Guanylate Cyclase Activator 2A; GUCA2A Peptide; hUroguanylin; Preproguanylin (104-119) amide (human); [Asn13, Tyr14]-Guanylin (human); H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH (Disulfide bridges: Cys4-Cys12, Cys7-Cys15)
EINECS	Contact for details

Quality Control

Our Uroguanylin (Human) is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A detailed Certificate of Analysis (COA) is provided, confirming compliance with our rigorous specifications for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the lyophilized powder desiccated. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Molecular Weight	1884.2 ± 2.0 Da
Single Impurity (HPLC)	≤ 1.0%
Water Content (Karl Fischer)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.