Description

Fmoc-L-Arg(Pbf)-Oh CAS NO 154445-77-9 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is critical for ensuring the correct and efficient incorporation of arginine into complex peptide sequences, particularly in the production of therapeutic peptides and research biochemicals. It is primarily used by pharmaceutical R&D laboratories, biotechnology companies, and CROs engaged in peptide drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated synthesis of peptides containing arginine residues.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening against biological targets.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of peptide linkers that connect cytotoxic drugs to monoclonal antibodies.
• Academic & Institutional Research: Fundamental tool for studying protein-protein interactions, signal transduction pathways, and enzyme mechanisms.

Basic Information

Product Name	Fmoc-L-Arg(Pbf)-Oh
CAS No.	154445-77-9
Molecular Formula	C34H48N4O7S
Molecular Weight	656.84 g/mol
Synonyms	Fmoc-Arg(Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Fmoc-L-arginine(Pbf)-OH; Fmoc-Arg(Pbf)-OH, 98+%; N-α-(9-Fluorenylmethoxycarbonyl)-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Fmoc-Arg(Pbf)-OH (Peptide Synthesis Grade); Fmoc-Arg(Pbf)-OH, Peptide Grade; Fmoc-Arg(Pbf)-OH, SPPS Reagent
EINECS	Contact for details

Quality Control

Our Fmoc-L-Arg(Pbf)-Oh is manufactured under strict quality control protocols to ensure consistency and purity suitable for sensitive peptide synthesis applications. Each batch is tested to meet high-performance standards, with typical purity exceeding 98.5% by HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and residual solvent levels is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% L-Isomer
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.