Description

(D-Lys(Nicotinoyl)1,β-(3-Pyridyl)-Ala3,3,4-Dichloro-D-Phe5,Asn6,D-Trp7,β-(3-Pyridyl)-D-Ala9,Nle11)-Substance P is a highly specific, synthetic peptide analog of the neuropeptide Substance P, engineered with multiple strategic amino acid substitutions. This compound matters as a potent and selective antagonist for neurokinin-1 (NK1) receptors, providing a critical research tool for studying pain signaling, neuroinflammation, and emesis pathways. It is primarily needed by pharmaceutical R&D teams, academic neuroscientists, and biotechnology companies engaged in developing novel therapeutics for central nervous system disorders and chemotherapy-induced nausea.

Application

• Neuroscience Research: A key pharmacological tool for investigating the role of Substance P and NK1 receptors in pain transmission, migraine, and neurogenic inflammation.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization for novel NK1 receptor antagonist candidates targeting depression, anxiety, and emesis.
• In Vitro & Ex Vivo Studies: Functional characterization of receptor binding affinity, selectivity, and intracellular signaling cascades in cell-based assays and tissue preparations.
• Preclinical Animal Studies: Evaluation of efficacy in animal models of inflammatory pain, neuropathic pain, and chemotherapy-induced nausea and vomiting (CINV).
• Biochemical Assay Standard: Serves as a reference standard in competitive binding assays (e.g., radioligand binding) to quantify receptor occupancy and inhibitor potency (IC50/Ki values).
• Mechanistic Pharmacology: Elucidation of downstream effector pathways modulated by NK1 receptor blockade, contributing to target validation studies.

Basic Information

Item	Details
Product Name	(D-Lys(Nicotinoyl)1,β-(3-Pyridyl)-Ala3,3,4-Dichloro-D-Phe5,Asn6,D-Trp7,β-(3-Pyridyl)-D-Ala9,Nle11)-Substance P
CAS No.	154427-06-2
Molecular Formula	C86H108Cl2N22O16
Molecular Weight	~1750.8 g/mol
Synonyms	Sendide; [D-Lys1(Nicotinoyl), β-(3-Pyridyl)-Ala3, 3,4-Dichloro-D-Phe5, Asn6, D-Trp7, β-(3-Pyridyl)-D-Ala9, Nle11]-Substance P; NK1 Receptor Antagonist (Sendide); Substance P (6-11) analog Sendide; Neurokinin-1 Antagonist Peptide; [D-Lys1(Nicotinoyl), D-3-Pal3, 3,4-DCl-D-Phe5, Asn6, D-Trp7,9, Nle11]-Substance P (5-11); Sendide TFA salt (if applicable)
EINECS	Contact for details

Quality Control

Every batch of (D-Lys(Nicotinoyl)1,β-(3-Pyridyl)-Ala3,3,4-Dichloro-D-Phe5,Asn6,D-Trp7,β-(3-Pyridyl)-D-Ala9,Nle11)-Substance P is synthesized and purified under cGMP-like conditions for research use. Our products undergo rigorous quality testing to ensure compliance with industry standards for peptide pharmaceuticals. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and content.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Content)	≥ 97% (by Amino Acid Analysis)
Water Content (KF)	≤ 5.0%
Acetate/TFA Content (HPLC)	Reported on COA
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.