Description

Napsagatran CAS NO 154397-77-0 is a high-purity synthetic organic compound belonging to the class of direct thrombin inhibitors. This compound is of significant interest in pharmaceutical research and development for its potent and selective anticoagulant properties. It serves as a critical intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers developing next-generation antithrombotic therapies targeting conditions such as deep vein thrombosis and stroke prevention.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of advanced anticoagulant drug candidates.
• Biochemical Research: Utilized as a reference standard or probe in studies of thrombin inhibition mechanisms and blood coagulation pathways.
• Preclinical Development: Serves as an active ingredient in formulation studies and in-vivo efficacy models for antithrombotic agents.
• Analytical Standard: Used for method development, calibration, and quality control in HPLC and LC-MS analysis within pharmaceutical QC laboratories.

Basic Information

Product Name	Napsagatran
CAS No.	154397-77-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	BIBR-953; BIBR 953; BIBR953; (2R,4R)-4-Methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid 1,2,2-trimethylhydrazide; Napsagatranum
EINECS	Contact for details

Quality Control

Our Napsagatran is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) documenting purity, impurities, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.