Description

(S)-(-)-Nadifloxacin is the pure (S)-enantiomer of the broad-spectrum fluoroquinolone antibiotic nadifloxacin. This specific stereoisomer is of significant interest in advanced pharmaceutical research and development due to its distinct biological activity profile. It is primarily utilized by R&D chemists and formulation scientists working on novel antibacterial agents, enantiomerically pure drugs, and topical dermatological preparations.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity chemical standard for analytical method development, validation, and quality control in API manufacturing.
• Enantioselective Drug Research: Used as a key intermediate or building block in the synthesis and study of stereospecific fluoroquinolone antibiotics.
• Mechanistic Studies: Employed in biochemical and microbiological research to investigate the structure-activity relationships (SAR) and mode of action of quinolone antibiotics.
• Impurity Profiling: Critical for identifying and quantifying the (S)-enantiomer as a potential impurity in batches of racemic nadifloxacin or its (R)-enantiomer.
• Formulation Development: Used in pre-clinical studies for developing new topical formulations targeting skin and soft tissue infections.

Basic Information

Product Name	(S)-(-)-Nadifloxacin
CAS No.	154357-42-3
Molecular Formula	C19H21FN2O4
Molecular Weight	360.38 g/mol
Synonyms	(S)-Nadifloxacin; (-)-Nadifloxacin; (S)-(-)-9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic Acid; (S)-9-Fluoro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid; (S)-OPC-7251; (S)-Acuatim; (S)-Fluxiderm
EINECS	Contact for details

Quality Control

Our (S)-(-)-Nadifloxacin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure high enantiomeric excess (e.e.) and chemical purity suitable for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% e.e.
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.