Description

Echistatin CAS NO 154303-05-6 is a potent and highly specific cyclic RGD-containing peptide that functions as a selective antagonist of integrin αIIbβ3 (GPIIb/IIIa). This compound is a critical research tool for studying platelet aggregation, cell adhesion mechanisms, and angiogenesis. It is essential for pharmaceutical R&D, biochemical research, and the development of novel anti-thrombotic agents.

Application

• Biomedical Research: Fundamental studies on integrin-mediated cell adhesion, signaling, and migration.
• Platelet Aggregation Studies: Used as a specific inhibitor to investigate the role of the αIIbβ3 integrin in thrombosis and hemostasis.
• Angiogenesis & Cancer Research: Exploration of tumor metastasis and vascular biology by blocking integrin interactions.
• Drug Discovery & Development: Serves as a reference standard and lead compound for designing new antiplatelet and anticancer therapeutics.
• Biochemical Assays: Utilized in ELISA, cell adhesion assays, and other in vitro diagnostic tests to validate integrin function.

Basic Information

Product Name	Echistatin
CAS No.	154303-05-6
Molecular Formula	C184H273N55O57S6
Molecular Weight	~5400 g/mol
Synonyms	Echistatin (Echis carinatus); ECIST_HUMAN; Integrin α-IIb/β-3 inhibitor; Platelet aggregation inhibitor peptide; RGD-containing disintegrin; GPIIb-IIIa antagonist; [Cys22-Cys37, Cys27-Cys42, Cys32-Cys53, Cys54-Cys65]-Echistatin; Cyclic Echistatin
EINECS	Contact for details

Quality Control

Our Echistatin is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and biological activity assays. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee product integrity for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	Specified per batch (typically in nM range for αIIbβ3 inhibition)
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.