Description

1-Phenyl-1-[4-(Trifluoromethyl)Phenyl]Methanamine is a specialized aromatic amine building block featuring a trifluoromethyl substituent, which imparts unique electronic and steric properties. This compound is valued for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where the CF₃ group is crucial for modulating lipophilicity and metabolic stability. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and advanced polymers.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	1-Phenyl-1-[4-(Trifluoromethyl)Phenyl]Methanamine
CAS No.	154233-38-2
Molecular Formula	C₁₄H₁₂F₃N
Molecular Weight	251.25 g/mol
Synonyms	α-(4-(Trifluoromethyl)phenyl)benzylamine; [4-(Trifluoromethyl)phenyl](phenyl)methanamine; 1-[4-(Trifluoromethyl)phenyl]-1-phenylethanamine (common misnomer); Benzenemethanamine, α-[4-(trifluoromethyl)phenyl]-; (4-Trifluoromethylbenzhydryl)amine; 4-Trifluoromethylbenzhydrylamine; 1-Phenyl-1-(4-trifluoromethylphenyl)methylamine
EINECS	Contact for details

Quality Control

Our production of 1-Phenyl-1-[4-(Trifluoromethyl)Phenyl]Methanamine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can provide material manufactured under quality management systems aligned with ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider the use of a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.