Description

Ethyl 2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)Propanoate is a high-purity, fluorinated indole derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role as a key chiral intermediate in the development of novel pharmaceutical agents, particularly in central nervous system (CNS) and oncology research. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for neurological and oncological targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for compounds containing fluorinated indole scaffolds.
• Process Chemistry: Serves as a critical intermediate in the scale-up and commercial synthesis of active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Potential use in creating fluorescent probes or biochemical tools due to the reactive amino and ester functional groups.
• Academic & Institutional Research: Employed in synthetic organic chemistry studies focused on heterocyclic and fluorinated compound synthesis.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom synthesis of more complex, proprietary molecules for clients.

Basic Information

Item	Details
Product Name	Ethyl 2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)Propanoate
CAS No.	154170-01-1
Molecular Formula	C₁₃H₁₅FN₂O₂
Molecular Weight	250.27 g/mol
Synonyms	3-(2-Amino-3-Ethoxy-3-Oxopropyl)-5-Fluoro-1H-Indole; Ethyl 2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)Propionate; 5-Fluoro-DL-tryptophan ethyl ester; 5-Fluoro-DL-Trp-OEt; 5-Fluoro Tryptophan Ethyl Ester; 154170-01-1; 3-(2-Amino-3-ethoxy-3-oxo-1-propyl)-5-fluoro-1H-indole
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring GMP-grade intermediates and compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.