Description

Diazepam Binding Inhibitor (39-75) CAS NO 153858-87-8 is a synthetic peptide fragment derived from the endogenous Diazepam Binding Inhibitor (DBI), a protein that modulates the activity of GABA-A receptors. This specific sequence is a critical research tool for investigating the neurobiological mechanisms of anxiety, stress response, and the regulation of benzodiazepine binding sites. It is essential for pharmaceutical R&D, academic neuroscience, and biotechnology laboratories focused on CNS drug discovery and neuropeptide signaling pathways.

Application

• Neuroscience Research: Used as a selective ligand to study the interaction between endogenous peptides and the GABA-A/benzodiazepine receptor complex.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in screening assays for novel anxiolytics, anticonvulsants, and neurosteroids.
• Biochemical Studies: Employed in competitive binding assays (e.g., radioligand binding) to characterize receptor subtypes and binding affinities.
• Mechanistic Pharmacology: Facilitates research into the role of DBI in stress, anxiety, and seizure disorders by modulating allosteric sites on GABA receptors.
• Peptide Chemistry & Proteomics: Acts as a substrate or standard in enzymatic degradation studies and mass spectrometry analysis of neuropeptides.

Basic Information

Product Name	Diazepam Binding Inhibitor (39-75)
CAS No.	153858-87-8
Molecular Formula	C174H286N52O51S
Molecular Weight	3975.5 g/mol
Synonyms	DBI (39-75); Diazepam Binding Inhibitor Fragment 39-75; Octadecaneuropeptide (ODN); DBI Peptide (39-75); Endozepine (39-75); Human Diazepam Binding Inhibitor (39-75); GABA Modulatory Peptide; Neuropeptide DBI Fragment.
EINECS	Contact for details

Quality Control

Our Diazepam Binding Inhibitor (39-75) is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the lyophilized powder desiccated. Avoid repeated freeze-thaw cycles of reconstituted solutions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Conforms to theoretical sequence
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.