Description

Boc-L-Arg(Alloc)2-OH DCHA is a protected derivative of the amino acid L-Arginine, featuring Boc (tert-butoxycarbonyl) and Alloc (allyloxycarbonyl) protecting groups, isolated as a dicyclohexylamine (DCHA) salt. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering orthogonal deprotection strategies for advanced solid-phase and solution-phase peptide chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of arginine residues with orthogonal side-chain protection.
• Solution-Phase Peptide Chemistry: Used in the synthesis of peptide fragments and conjugates where selective deprotection is required.
• Pharmaceutical Research: Serves as a crucial raw material in the R&D of peptide-based drugs targeting various diseases.
• Protease Inhibitor Development: Employed in creating arginine-rich sequences that mimic natural substrates for enzyme inhibition studies.
• Bioconjugation: Facilitates the site-specific modification of peptides due to its selectively removable protecting groups.
• Chemical Biology Probes: Used to synthesize labeled or tagged peptides for studying protein-protein interactions and cellular processes.

Basic Information

Product Name	Boc-L-Arg(Alloc)2-OH DCHA
CAS No.	153765-37-8
Molecular Formula	C₂₈H₅₀N₆O₈
Molecular Weight	598.73 g/mol
Synonyms	N2-[(1,1-Dimethylethoxy)carbonyl]-N5-[(2-propen-1-yloxy)carbonyl]-Nω-[(2-propen-1-yloxy)carbonyl]-L-ornithine DCHA salt; Boc-Arg(Alloc)2-OH·DCHA; tert-Butoxycarbonyl-L-arginine(Alloc)2 dicyclohexylamine salt; Nα-Boc-Nδ,Nω-bis(Alloc)-L-arginine DCHA salt; (2S)-5-{[(Allyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}-N-[(allyloxy)carbonyl]pentanoic acid compound with N-cyclohexylcyclohexanamine; Boc-L-Arg(Alloc)2-OH Dicyclohexylamine Salt
EINECS	Contact for details

Quality Control

Our Boc-L-Arg(Alloc)2-OH DCHA is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.