Description

2,4-Dichloro-5-Trichloromethylpyrimidine is a versatile halogenated pyrimidine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring reactive chlorine atoms and a trichloromethyl group, makes it a valuable building block for constructing complex heterocyclic systems. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for antiviral and anticancer agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the pyrimidine core is a key pharmacophore.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials and liquid crystals.
• Fine Chemical Production: Employed in custom synthesis and the manufacture of specialty chemicals for various industrial applications.
• Cross-Coupling Reactions: The chlorine atoms provide excellent sites for palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination to create diverse compound libraries.
• Nucleoside Analog Development: Used in medicinal chemistry for modifying nucleoside structures to explore new therapeutic candidates.

Basic Information

Product Name	2,4-Dichloro-5-Trichloromethylpyrimidine
CAS No.	153600-16-9
Molecular Formula	C5HCl5N2
Molecular Weight	280.29 g/mol
Synonyms	5-(Trichloromethyl)-2,4-dichloropyrimidine; 2,4-Dichloro-5-(trichloromethyl)pyrimidine; Pyrimidine, 2,4-dichloro-5-(trichloromethyl)-; NSC 405124; 2,4-Dichloro-5-trichloromethyl-pyrimidine
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-5-Trichloromethylpyrimidine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and reliability for your synthetic processes. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.