Description

4-(3'-Hydroxyphenyl)Amino-6,7-Dimethoxyquinazoline, Hcl is a high-purity, synthetically derived quinazoline derivative. This compound is a critical pharmaceutical intermediate and research chemical valued for its role in the development of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract manufacturing organizations (CMOs) engaged in oncology and kinase inhibitor discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and other small-molecule therapeutics.
• Biochemical Research: Used as a reference standard or active compound in enzymatic assays and biological pathway studies.
• Oncology Drug Discovery: Serves as a core scaffold for developing compounds targeting specific cancer cell signaling pathways.
• Chemical Synthesis: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Academic Research: Utilized in university and institutional labs for pharmacological and biochemical investigations.
• Preclinical Development: Supports the early-stage development and testing of potential drug candidates.

Basic Information

Item	Detail
Product Name	4-(3'-Hydroxyphenyl)Amino-6,7-Dimethoxyquinazoline, Hcl
CAS No.	153437-55-9
Molecular Formula	C₁₆H₁₆N₄O₃ • HCl
Molecular Weight	348.78 g/mol
Synonyms	4-[(3-Hydroxyphenyl)amino]-6,7-dimethoxyquinazoline hydrochloride; 4-(3-Hydroxy-anilino)-6,7-dimethoxy-quinazoline hydrochloride; 6,7-Dimethoxy-4-(3-hydroxyphenylamino)quinazoline HCl; PD 153035 HCl; ZD 1839 Intermediate; Gefitinib Intermediate; EGFR Inhibitor Intermediate; Tyrphostin AG 1517
EINECS	Contact for details

Quality Control

Our 4-(3'-Hydroxyphenyl)Amino-6,7-Dimethoxyquinazoline, Hcl is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters to ensure compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.