Description

Asimadoline is a highly selective κ-opioid receptor agonist with significant research and therapeutic potential. This compound is valued for its targeted pharmacological activity, which makes it a critical tool for investigating pain pathways and developing novel analgesics. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and academic institutions focused on neuropharmacology and drug discovery.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for novel pain management therapies.
• Neuropharmacology Studies: Used as a selective tool compound to study the role and function of κ-opioid receptors in the central and peripheral nervous systems.
• Analgesic Drug Discovery: Serves as a lead compound or benchmark in the development of new, non-addictive analgesic agents with reduced side-effect profiles.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to identify and characterize new receptor ligands.
• Academic Research: Utilized in university laboratories for fundamental research on opioid receptor signaling, pain mechanisms, and related physiological processes.
• GMP Manufacturing: Sourced as a starting material or intermediate for the cGMP-compliant synthesis of finished dosage forms for clinical trials.

Basic Information

Product Name	Asimadoline
CAS No.	153205-63-1
Molecular Formula	C₂₃H₂₉N₃O₃
Molecular Weight	395.50 g/mol
Synonyms	EMD 61753; (2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-Amino-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanamido]-3-(1H-indol-3-yl)propanamido]acetic acid; Asimadoline hydrochloride; κ-opioid receptor agonist EMD 61753; (S)-2-[(R)-2-[(S)-2-[(R)-2-Amino-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanamido]-3-(1H-indol-3-yl)propanamido]acetic acid
EINECS	Contact for details

Quality Control

Our Asimadoline is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines to support its use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.