Description

Asimadoline is a selective κ-opioid receptor agonist with significant research and development interest. This compound is a key intermediate and active pharmaceutical ingredient (API) in the development of novel therapeutics targeting visceral pain and gastrointestinal disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions engaged in neuropharmacology and gastroenterology research.

Application

• Pharmaceutical Research & Development: As a critical intermediate or reference standard in the synthesis and development of new κ-opioid receptor-targeting drugs.
• Preclinical Studies: Used in animal models to investigate mechanisms and efficacy for treating conditions like irritable bowel syndrome (IBS) and other functional GI disorders.
• Analytical Reference Standard: Serves as a high-purity standard for method development, validation, and quality control in analytical laboratories (HPLC, LC-MS).
• Clinical Trial Material (CTM): Supplied under GMP guidelines for use in the manufacturing of investigational medicinal products for human clinical trials.
• Mechanistic Pharmacology: A tool compound for studying κ-opioid receptor signaling pathways and their role in pain modulation and visceral sensitivity.

Basic Information

Item	Details
Product Name	Asimadoline
CAS No.	153205-46-0
Molecular Formula	C17H23N3O2
Molecular Weight	301.39 g/mol
Synonyms	EMD 61753; (2S)-N-Methyl-N-[(5R,6R,8S)-6-(pyrrolidin-1-ylmethyl)-1-oxaspiro[4.5]decan-8-yl]-2-[(2R)-2,3-dihydro-1H-inden-2-yl]acetamide; Asimadoline hydrochloride; 1-Oxa-8-azaspiro[4.5]decane-8-acetamide derivative
EINECS	Contact for details

Quality Control

Our Asimadoline is manufactured and controlled under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including identity confirmation by IR and NMR, purity determination by HPLC, and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.