Description

Glycoprotein IIb Fragment (656-667) is a synthetic peptide fragment corresponding to a specific sequence of the platelet integrin glycoprotein IIb/IIIa complex. This compound is of significant value in biochemical and pharmacological research for studying platelet aggregation and thrombosis mechanisms. It serves as a critical tool for researchers and developers in the pharmaceutical and life sciences industries, particularly those focused on cardiovascular disease, antiplatelet drug discovery, and hematology.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of platelet activation and the fibrinogen binding site on GPIIb/IIIa.
• Drug Discovery & Development: Serves as a key reagent for screening and evaluating potential antiplatelet and antithrombotic compounds that target the integrin αIIbβ3.
• In Vitro Diagnostics (IVD): Employed in the development of assay kits and reagents designed to measure platelet function or detect platelet-related disorders.
• Antibody Production & Characterization: Acts as an immunogen or binding target for generating and testing monoclonal antibodies specific to the GPIIb/IIIa receptor.
• Cell Adhesion Studies: Utilized in experiments investigating the molecular basis of cell-cell and cell-matrix interactions mediated by integrins.
• Academic & Institutional Research: Fundamental tool for universities and research institutes exploring hemostasis, thrombosis, and cardiovascular biology.

Basic Information

Product Name	Glycoprotein IIb Fragment (656-667)
CAS No.	152846-14-5
Molecular Formula	C58H94N18O19S
Molecular Weight	1331.5 g/mol
Synonyms	GPIIb Fragment (656-667); Integrin α-IIb Fragment (656-667); H-Gly-Asp-Val-Pro-Gln-Thr-Leu-Phe-Pro-Lys-Ala-Gly-OH; Platelet Glycoprotein IIb (656-667); αIIb (656-667) Peptide; CD41b (656-667); GPIIb/IIIa Inhibitor Peptide Fragment; Arg-Gly-Asp (RGD) mimetic peptide sequence.
EINECS	Contact for details

Quality Control

Our Glycoprotein IIb Fragment (656-667) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, amino acid analysis, and other critical quality attributes to ensure it meets the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption. Aliquot into smaller working quantities to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Net Peptide Content	≥ 70%
Water Content (KF)	≤ 8.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.