Description

D-Proline, 4-Hydroxy-2-Methyl-, (4R)-Rel- (9Ci) is a non-proteinogenic, chiral proline derivative that serves as a sophisticated building block in advanced organic synthesis. Its value lies in its unique stereochemistry and functional groups, which enable the precise construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in protease inhibitor and peptidomimetic design.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce high enantioselectivity.
• Peptide Chemistry: Used to introduce conformational constraints or novel functionalities into synthetic peptides to modulate their biological activity and stability.
• Agrochemical Research: Serves as a building block for developing advanced, chiral active ingredients with improved efficacy and environmental profiles.
• Biochemical Research: Utilized in enzyme studies and as a precursor for labeled compounds in metabolic pathway analysis.
• Material Science: Investigated for the synthesis of specialized polymers and functional materials with tailored properties.

Basic Information

Product Name	D-Proline, 4-Hydroxy-2-Methyl-, (4R)-Rel- (9Ci)
CAS No.	152722-91-3
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(4R)-4-Hydroxy-2-methyl-D-proline; (2R,4R)-4-Hydroxy-2-methylproline; rel-(4R)-4-Hydroxy-2-methyl-D-proline; 4-Hydroxy-2-methyl-D-proline; D-4-Hydroxy-2-methylproline; (4R)-4-Hydroxy-2-methylpyrrolidine-2-carboxylic acid; 152722-91-3; 4-Hydroxy-2-methylproline (D-isomer)
EINECS	Contact for details

Quality Control

Every batch of D-Proline, 4-Hydroxy-2-Methyl-, (4R)-Rel- (9Ci) is produced and tested under strict quality management protocols to ensure identity, purity, and consistency. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and chemical purity, verified by techniques such as HPLC, NMR, and optical rotation. A Certificate of Analysis (COA) is supplied with each shipment, and custom synthesis to meet specific pharmacopeial (e.g., USP) or internal specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.