Description

(Tyr36)-Hypercalcemia Of Malignancy Factor (1-36) Amide (Chicken) is a synthetic peptide analog of the parathyroid hormone-related protein (PTHrP) fragment. This compound is a critical research tool for studying hypercalcemia of malignancy, a serious metabolic complication associated with various cancers. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers investigating calcium metabolism, bone biology, and oncological pathways. The product is supplied as a high-purity, lyophilized powder to ensure reliable and reproducible experimental results.

Application

• Biomedical Research: Fundamental studies on the role of PTHrP in cancer-induced hypercalcemia and bone metastasis.
• Drug Discovery & Development: Screening and validation of potential therapeutic agents targeting the PTH/PTHrP receptor pathway.
• Assay Development: Used as a reference standard or calibrator in the development of immunoassays (e.g., ELISA, RIA) for PTHrP detection.
• Signal Transduction Studies: Investigating intracellular signaling cascades (e.g., cAMP activation) mediated by PTHrP receptor binding.
• Academic & Clinical Research: Exploring the pathophysiology of humoral hypercalcemia of malignancy (HHM) and related endocrine disorders.
• Peptide Chemistry Reference: Serving as a model compound for studying peptide stability, modification, and structure-activity relationships (SAR).

Basic Information

Product Name	(Tyr36)-Hypercalcemia Of Malignancy Factor (1-36) Amide (Chicken)
CAS No.	152617-91-9
Molecular Formula	C194H311N57O55S
Molecular Weight	4299.0 g/mol (approximate)
Synonyms	PTHrP (1-36) Amide, Chicken; Parathyroid Hormone-Related Protein (1-36) Amide (Chicken); [Tyr36]PTHrP(1-36)NH2; Hypercalcemic Factor of Malignancy (1-36) Amide; HHM Factor (1-36); PTH-like Peptide; PLP; Osteostatin precursor fragment; ALP (Adenylate Cyclase-Stimulating Protein).
EINECS	Contact for details

Quality Control

Every batch of (Tyr36)-Hypercalcemia Of Malignancy Factor (1-36) Amide (Chicken) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity (HPLC), peptide content, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.