Description

[Methyl-D-Phe 6, D-Trp 7,9, Leu 10-Psi(Ch2Nh)Leu 11]-Substance P Fragment 6-11 is a synthetic peptide analog, specifically a pseudopeptide derivative of the neuropeptide Substance P. This compound is a potent and selective antagonist of the neurokinin-1 (NK1) receptor, making it a critical research tool for studying neurogenic inflammation, pain pathways, and central nervous system disorders. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, pharmacology, and drug discovery programs.

Application

• Neuroscience Research: As a selective NK1 receptor antagonist for investigating the role of Substance P in pain transmission, migraine, anxiety, and depression.
• Pharmacological Studies: Used in in vitro and in vivo models to characterize receptor binding, signal transduction, and the physiological effects of neurokinin receptor blockade.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel therapeutics targeting neurokinin receptors for conditions like emesis, inflammatory diseases, and psychiatric disorders.
• Biochemical Assays: Employed in high-throughput screening (HTS) and functional assays to identify and validate new NK1 receptor modulators.
• Academic & Clinical Research: Fundamental tool for exploring neurogenic inflammation, bronchoconstriction, and the interplay between the nervous and immune systems.

Basic Information

Item	Details
Product Name	[Methyl-D-Phe 6, D-Trp 7,9, Leu 10-Psi(Ch2Nh)Leu 11]-Substance P Fragment 6-11
CAS No.	152369-60-3
Molecular Formula	C58H78N14O8
Molecular Weight	1091.3 g/mol
Synonyms	Substance P (6-11) analog, psi[CH2NH]Leu11; [D-Arg1,D-Phe5,D-Trp7,9,Leu11]Substance P; NK1 Receptor Antagonist (6-11 fragment); Neurokinin-1 Antagonist Peptide; Pseudopeptide Substance P Antagonist; (6-11)-Substance P, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-; [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P (6-11)
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and mass spectrometry (MS) for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on purity, amino acid analysis, and peptide content. Our quality commitment ensures material suitable for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at low temperature. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, acetic acid; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.