Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(4-Methoxyphenyl)-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of antibacterial agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of next-generation quinolone and fluoroquinolone antibiotics. The precise molecular architecture of this intermediate enables the fine-tuning of pharmacological properties in final drug candidates.

Application

• Key Intermediate for Antibacterial APIs: Serves as a crucial building block in the synthesis of advanced fluoroquinolone antibiotics.
• Pharmaceutical R&D: Used in medicinal chemistry for the research and development of new therapeutic agents targeting bacterial infections.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling up production for clinical trial material and commercial API manufacturing.
• Reference Standard: Can be utilized as a high-purity analytical reference standard for quality control and method development.
• Custom Synthesis: A starting material for the custom synthesis of more complex, structurally related molecules for biological screening.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(4-Methoxyphenyl)-4-Oxo-
CAS No.	152247-02-4
Molecular Formula	C20H16FNO4
Molecular Weight	353.35 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(4-methoxyphenyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-methoxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 7-(4-Methoxyphenyl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; Gatifloxacin Intermediate; AM-1155 Intermediate; PD-135432 Intermediate; GTX Intermediate; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methoxyphenyl)-3-quinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent Good Manufacturing Practice (GMP) principles where applicable. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting customer specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support compliance with major pharmacopoeial and regulatory standards such as ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.