Description

3-Quinolinecarboxylic Acid, 7-(3-Aminohexahydro-2-Oxo-1H-Azepin-1-Yl)- 1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research importance. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, valued for its complex molecular architecture which imparts critical biological activity. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical synthesis facilities focused on next-generation antimicrobial agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Used in medicinal chemistry programs to develop new antibacterial agents with improved potency and spectrum of activity.
• API (Active Pharmaceutical Ingredient) Synthesis: Serves as a key intermediate in the multi-step production of bulk active pharmaceutical substances.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale production studies for new drug molecules.
• Academic & Institutional Research: Used in university and institutional labs for biochemical and pharmacological studies related to bacterial DNA gyrase and topoisomerase IV inhibition.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-(3-Aminohexahydro-2-Oxo-1H-Azepin-1-Yl)- 1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-4-Oxo-
CAS No.	151895-29-3
Molecular Formula	C20H21F2N3O4
Molecular Weight	405.40 g/mol
Synonyms	1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-amino-2-oxo-1-azepanyl)-4-oxo-3-quinolinecarboxylic acid; 7-(3-Amino-2-oxo-1-azepanyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; Intermediate for Sitafloxacin; Sitafloxacin Intermediate; DU-6859a Intermediate; (7S)-7-[(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (related stereoisomer); Fluoroquinolone Intermediate 151895-29-3.
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid, 7-(3-Aminohexahydro-2-Oxo-1H-Azepin-1-Yl)- 1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-4-Oxo- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D and synthesis. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.