Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(1-Oxohexyl)-1-Piperazinyl]- is a high-purity advanced pharmaceutical intermediate (API intermediate) with a complex heterocyclic structure. This compound is of critical importance in the synthesis of novel fluoroquinolone antibiotics, offering a key building block for research and development. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and fine chemical suppliers engaged in the development of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of new fluoroquinolone antibiotic candidates.
• Antibacterial Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies to optimize antibacterial potency and spectrum.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of API manufacturing processes.
• Fine Chemical Synthesis: Building block for creating specialized chemical libraries and custom-synthesized compounds for biological screening.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP and non-GMP production runs.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-[4-(1-Oxohexyl)-1-Piperazinyl]-
CAS No.	151602-46-9
Molecular Formula	C23H26FN3O4
Molecular Weight	427.47 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxohexyl)-1-piperazinyl]-3-quinolinecarboxylic acid; 7-(4-Hexanoylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Gatifloxacin Intermediate; AM-1155 Intermediate; Hexanoyl Piperazine Derivative of Gatifloxacin Core; 1-Cyclopropyl-6-fluoro-7-(4-hexanoylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.