Description

(E)-1,3-Dipropyl-7-Methyl-8-(2-(4-Propoxyphenyl)Ethenyl)-3,7-Dihydro-1 H-Purine-2,6-Dione is a high-purity, synthetic xanthine derivative with a defined stereochemistry, offering a critical building block for advanced pharmaceutical research and development. This compound is valued for its role as a key intermediate in the synthesis of novel adenosine receptor antagonists and other bioactive molecules targeting the central nervous system. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery programs for neurological and cardiovascular disorders.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potent and selective adenosine A1 and A2A receptor antagonists.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Biochemical Research: Employed as a reference standard or tool compound in pharmacological assays to study purinergic signaling pathways.
• Chemical Synthesis: Acts as a specialized building block for creating complex heterocyclic libraries for high-throughput screening.
• Academic Research: Utilized in university and institutional labs for fundamental research on xanthine-based chemistry and its biological implications.

Basic Information

Item	Details
Product Name	(E)-1,3-Dipropyl-7-Methyl-8-(2-(4-Propoxyphenyl)Ethenyl)-3,7-Dihydro-1 H-Purine-2,6-Dione
CAS No.	151539-44-5
Molecular Formula	C23H28N4O3
Molecular Weight	408.50 g/mol
Synonyms	KW-6002 (Istradefylline Intermediate); (E)-Istradefylline Intermediate; (E)-8-(3,4-Dimethoxystyryl)-1,3-dipropyl-7-methylxanthine (related analog); 1,3-Dipropyl-8-[(E)-2-(4-propoxyphenyl)ethenyl]-7-methyl-3,7-dihydro-1H-purine-2,6-dione; (E)-1,3-Dipropyl-8-[2-(4-propoxyphenyl)vinyl]-7-methylxanthine; 8-[(E)-2-(4-Propoxyphenyl)ethenyl]-1,3-dipropyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
EINECS	Contact for details

Quality Control

Our (E)-1,3-Dipropyl-7-Methyl-8-(2-(4-Propoxyphenyl)Ethenyl)-3,7-Dihydro-1 H-Purine-2,6-Dione is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.