Description

2-Oxohistidine is a modified amino acid derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a critical intermediate and reference standard for studying oxidative stress, protein damage, and advanced glycation end-products (AGEs). It is essential for researchers and manufacturers in the fields of proteomics, diagnostic assay development, and therapeutic agent discovery. The product is supplied under stringent quality control to ensure reliability for sensitive applications.

Application

• Biochemical Research: Used as a key reference standard in the study of protein oxidation and post-translational modifications.
• Diagnostic Development: Serves as a critical antigen or calibrator in the development of immunoassays for detecting oxidative stress biomarkers.
• Pharmaceutical R&D: Employed as an intermediate in the synthesis of novel compounds targeting age-related diseases and metabolic disorders.
• Proteomics & Metabolomics: Acts as a standard for mass spectrometry and chromatographic analysis to identify and quantify modified amino acids in complex biological samples.
• Nutritional Science Research: Utilized in studies investigating the impact of dietary components on protein damage and aging.
• Quality Control Standards: Provides a certified reference material for ensuring accuracy in analytical laboratories.

Basic Information

Product Name	2-Oxohistidine
CAS No.	151436-49-6
Molecular Formula	C6H9N3O3
Molecular Weight	171.16 g/mol
Synonyms	2-Oxo-L-histidine; L-2-Oxohistidine; Oxohistidine; 2-Oxo-histidine; (2S)-2-Amino-3-(5-oxo-4,5-dihydro-1H-imidazol-4-yl)propanoic acid; Histidine, 2-oxo-; 2-Oxo-L-histidine monohydrate (common hydrate form)
EINECS	Contact for details

Quality Control

Our 2-Oxohistidine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to ISO 9001 quality management principles to support research and development requiring reliable, high-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% L-isomer
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.