Description

R-Tirofiban Hcl is a high-purity, non-peptide antagonist of the platelet glycoprotein IIb/IIIa receptor, a key target in antiplatelet therapy. This compound is critical for the research and development of novel antithrombotic agents, offering a specific mechanism to inhibit platelet aggregation. It is primarily utilized by pharmaceutical R&D teams and fine chemical suppliers focused on cardiovascular drug discovery and generic API synthesis.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active component in the development and production of antiplatelet medications.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation of tirofiban-based products.
• Biochemical Research: A vital tool for in-vitro and in-vivo studies investigating platelet physiology, thrombosis mechanisms, and cardiovascular diseases.
• Process Development: Employed in the optimization of synthetic routes and scale-up processes for the commercial manufacturing of tirofiban hydrochloride.
• Formulation Studies: Used in pre-formulation and formulation research to develop stable and bioavailable dosage forms, such as injectable solutions.

Basic Information

Product Name	R-Tirofiban Hcl
CAS No.	151414-72-1
Molecular Formula	C22H36N2O5S · HCl
Molecular Weight	477.06 g/mol
Synonyms	Tirofiban Hydrochloride; L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, monohydrochloride; (R)-Tirofiban HCl; MK-383 Hydrochloride; Aggrastat (brand name reference); GP IIb/IIIa Inhibitor; N-(Butylsulfonyl)-4-[4-(4-piperidinyl)butoxy]-L-phenylalanine Monohydrochloride
EINECS	Contact for details

Quality Control

Our R-Tirofiban Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the R-enantiomer, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.