Description

3,5-Difluoro-2-Nitrophenol is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both electron-withdrawing nitro and fluoro substituents, makes it a critical building block for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active ingredients and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring a difluorophenol core structure.
• Agrochemical Synthesis: Used in the development of novel herbicides, pesticides, and fungicides where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Dye & Pigment Manufacturing: Employed in the production of specialized dyes and pigments where the nitro and fluoro groups modify color and fastness properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	3,5-Difluoro-2-Nitrophenol
CAS No.	151414-46-9
Molecular Formula	C6H3F2NO3
Molecular Weight	175.09 g/mol
Synonyms	2-Nitro-3,5-difluorophenol; 3,5-Difluoro-2-nitro-phenol; Phenol, 3,5-difluoro-2-nitro-; 3,5-Difluoro-2-hydroxy-nitrobenzene; 2-Hydroxy-3,5-difluoronitrobenzene; 3,5-Difluoro-2-nitrophenyl alcohol; 151414-46-9 (CAS)
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-2-Nitrophenol is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.