Description

Pyroglutamylasparagine Diketopiperazine is a specialized cyclic dipeptide (2,5-diketopiperazine) formed from the condensation of pyroglutamic acid and asparagine. This compound matters as a high-purity biochemical building block and a potential intermediate for advanced research in peptide chemistry and medicinal discovery. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug development, proteomics, and as a reference standard.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or scaffold in the synthesis of novel peptide-based therapeutics and bioactive molecules.
• Biochemical Reference Standard: Used for analytical method development, calibration, and quality control in laboratories studying diketopiperazines or related peptide derivatives.
• Proteomics & Peptide Chemistry: Acts as a model compound for studying cyclization reactions, peptide stability, and structure-activity relationships (SAR).
• Cosmeceutical Ingredient Research: Investigated for potential bioactive properties in advanced skincare and cosmetic formulations.
• Academic & Institutional Research: Utilized in university and institutional labs for fundamental studies in organic chemistry and bioorganic mechanisms.

Basic Information

Product Name	Pyroglutamylasparagine Diketopiperazine
CAS No.	151367-95-2
Molecular Formula	C9H12N4O5
Molecular Weight	256.22 g/mol
Synonyms	1-(5-Oxo-L-prolyl)-L-asparagine 2,5-diketopiperazine; Cyclo(L-pyroglutamyl-L-asparagine); L-Pyroglutamyl-L-asparagine anhydride; 2,5-Piperazinedione, 1-(5-oxo-L-prolyl)-L-asparagine-; Pyroglutamyl-Asparagine DKP; PG-Asp DKP; (3S,8aS)-3-[(2S)-5-Oxo-2-pyrrolidinyl]-2,3,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazine-1,4-dione
EINECS	Contact for details

Quality Control

Our Pyroglutamylasparagine Diketopiperazine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.