Description

3-Chloro-5-(Trifluoromethoxy)A is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its ability to introduce both chlorine and trifluoromethoxy substituents, which are key motifs for modulating the physicochemical and biological properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes, enzyme inhibitors, and labeled compounds for diagnostic applications.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects and scale-up processes under cGMP or ISO 9001 standards.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethoxy)A
CAS No.	151276-13-0
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	1-Chloro-3-(trifluoromethoxy)benzene; 3-Chloro-1-(trifluoromethoxy)benzene; (3-Chlorophenyl) trifluoromethyl ether; m-Chloro(trifluoromethoxy)benzene; 3-Chloro-alpha,alpha,α-trifluoroanisole; 3-Chlorophenyl trifluoromethyl ether; 3-Chloro-5-(trifluoromethoxy)benzene (common alternate numbering); 151276-13-0 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-5-(Trifluoromethoxy)A adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to confirm identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with various pharmacopeial or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Refractive Index	To be provided on COA
Density	To be provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.