Description

D-Proline, 4-Methoxy-, cis- (9Ci) is a non-proteinogenic, chiral proline derivative characterized by a methoxy substituent at the 4-position. This compound is a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the construction of complex molecules with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and asymmetric catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including protease inhibitors and other biologically active compounds.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints and modify the pharmacokinetic properties of peptide-based drug candidates.
• Asymmetric Catalysis: Serves as a precursor or ligand component in the design of chiral catalysts for enantioselective synthesis.
• Chemical Biology Research: Employed as a probe or building block in the study of enzyme mechanisms and protein-ligand interactions.
• Agrochemical Research: Potential intermediate in the synthesis of chiral, bioactive molecules for crop protection.
• Academic & Process Chemistry: A versatile starting material for methodological studies in organic synthesis and scale-up process development.

Basic Information

Product Name	D-Proline, 4-Methoxy-, cis- (9Ci)
CAS No.	151273-50-6
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(2R,4S)-4-Methoxy-D-proline; cis-4-Methoxy-D-proline; (2R,4S)-4-Methoxypyrrolidine-2-carboxylic acid; D-4-Methoxyproline; 4-Methoxy-D-proline; (R)-4-Methoxyproline; 4-Methoxy-(2R,4S)-proline
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Methoxy-, cis- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality systems support development from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Enantiomeric Purity (Chiral HPLC)	≥98.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.