Description

7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 10-Amino-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-, (S)- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure containing a fluorine atom and a carboxylic acid group. This compound is of significant commercial importance as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is primarily required by R&D laboratories, custom synthesis providers, and large-scale pharmaceutical manufacturers engaged in the development and production of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of advanced fluoroquinolone antibiotics.
• Antibacterial Drug Research: Serves as a core scaffold for medicinal chemistry and structure-activity relationship (SAR) studies aimed at discovering new antibacterial agents.
• Process Chemistry Development: Used in the optimization and scale-up of API manufacturing processes under cGMP conditions.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory submissions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized compounds for client projects.

Basic Information

Product Name	7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 10-Amino-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-, (S)- (9Ci)
CAS No.	151250-74-7
Molecular Formula	C₁₄H₁₂FN₃O₄
Molecular Weight	305.26 g/mol
Synonyms	(S)-10-Amino-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; (S)-AMFC; S-(-)-Ofloxacin Intermediate; S-(-)-Ofloxacin Carboxylic Acid; Levofloxacin Intermediate; (3S)-10,11-Dihydro-3-methyl-9-fluoro-7-oxo-3H,7H-[1,4]oxazino[3,2,1-ij]quinoline-6-carboxylic acid; 10-Amino-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid, (S)-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support regulatory requirements and can supply material manufactured under cGMP guidelines for advanced clinical and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.