Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-7-(Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl)-4-Oxo-, (4As-Cis)- CAS NO 151213-15-9 is a high-purity, advanced pharmaceutical intermediate characterized by its complex, fused heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of novel fluoroquinolone antibiotics, where its specific stereochemistry and functional groups are critical for biological activity. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical suppliers engaged in developing next-generation antimicrobial therapies.

Application

• Critical Intermediate for Fluoroquinolone Antibiotics: Serves as a core scaffold in the research and production of advanced antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of complex antibiotic molecules at pilot and commercial scales.
• Process Chemistry Optimization: Utilized for developing and scaling up efficient, cost-effective synthetic routes for antibiotic production.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Fine Chemical & Custom Synthesis: Supplied to contract research organizations (CROs) and CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-7-(Octahydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl)-4-Oxo-, (4As-Cis)-
CAS No.	151213-15-9
Molecular Formula	C20H21F2N3O3
Molecular Weight	389.40 g/mol
Synonyms	(4aS)-1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid (4aS-cis)-; Intermediate for Garenoxacin; Garenoxacin intermediate; T-3811 intermediate; OPC-17116 intermediate; 6-Fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-8-methoxy-7-[(3aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.