Description

1-Cyclopropyl-6,8-Difluoro-4-Oxo-7-((4Ar,7Ar)-Tetrahydro-1H-Pyrrolo[3,4-B]Pyridin-6(2H,7H,7Ah)-Yl)-1,4-Dihydroquinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance due to its critical role as a key building block in the synthesis of novel antibacterial agents. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of next-generation quinolone and fluoroquinolone-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antibacterial drugs, particularly advanced fluoroquinolone antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component for research into new chemical entities (NCEs) targeting resistant bacterial strains.
• Biochemical Research: Used in pharmacological studies to investigate structure-activity relationships (SAR) and mechanism of action for DNA gyrase inhibitors.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of clinical trial materials.
• Reference Standard: High-purity grades are utilized as analytical standards for quality control and regulatory submissions.

Basic Information

Product Name	1-Cyclopropyl-6,8-Difluoro-4-Oxo-7-((4Ar,7Ar)-Tetrahydro-1H-Pyrrolo[3,4-B]Pyridin-6(2H,7H,7Ah)-Yl)-1,4-Dihydroquinoline-3-Carboxylic Acid
CAS No.	151096-44-5
Molecular Formula	C20H19F2N3O3
Molecular Weight	387.38 g/mol
Synonyms	7-[(4aR,7aR)-Hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl]-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-3-quinolinecarboxylic acid; (4aR,7aR)-6-[1-Cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydro-3-quinolinyl]decahydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid; Garenoxacin Intermediate; DW-224a Intermediate; T-3811 Intermediate; OPC-17116 Intermediate
EINECS	Contact for details

Quality Control

Our production of 1-Cyclopropyl-6,8-Difluoro-4-Oxo-7-((4Ar,7Ar)-Tetrahydro-1H-Pyrrolo[3,4-B]Pyridin-6(2H,7H,7Ah)-Yl)-1,4-Dihydroquinoline-3-Carboxylic Acid adheres to stringent quality management systems. The material is manufactured under controlled conditions and undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.